Endocrine Abstracts

Introduction: One of the often-discussed topics in the management guidelines for Type 1 Diabetes Mellitus (T1DM) is the ideal time gap that should exist between patient check-ups. A period of three to six months is usually recommended, which sometimes is difficult to achieve due to the high number of patients. But to what extent does the time gap between appointments in the follow-up of T1DM patients affect their diabetes’ control?Objectives: To kn...

The screening for primary aldosteronism (PA) is based on the aldosterone/renin ratio (ARR), which is calculated with the plasma renin activity (PRA) as denominator. A direct measurement of active renin (DRA) is being used as an alternative to PRA, but its diagnostic performance remains uncertain.Aim of the study was to head-to-head compare the ARR based on PRA (ARR-P) to on DRA (ARR-D), at baseline and post-captopril, for identifying aldosterone-producin...

Background: Classic 21-hydroxylase deficiency, due to severe mutations in CYP21B gene, is an uncommon disease (1/ 150 000). Salt-wasting form accounts for 75% of the cases and turns up with gluco- and mineralocorticoid deficiency as well as feminine hermaphroditism. Although wide psycho-social repercussion especially in women is known, the rarity of the disease and losses in follow-up may lead to a scarce clinical experience. We present 3 adult patients with CAH- SW followed r...

Despite advances in the management of last years, diabetes and its complications are still the most frequent cause of admission in Endocrine Departments. Nowadays, in our Hospital, 60% of admissions are due to Diabetes, and more than a half of these are diabetic ketoacidosis (DKA) (35.4%).Objective: Analize DKA episodes in our medical area in the last 12 years and compare them divided in two periods.Methods: Divide DKA episodes in ...

Introduction: Recent studies defend the measurements of insulin resistance and β-cell function to assess the endocrine pancreatic function in patients with cystic fibrosis (CF). HOMA-IR indexes greater than 1 translate insulin resistance and HOMA-%β values lower than 100% imply an altered β-cell function.Aim: To describe insulin resistance and β-cell function using HOMA-IR and HOMA-%β indexes in patients with CF and compare them ...

Introduction: Insulin resistance (IR), a pathological state of low sensitivity to insulin in humans and animlas, is closely associated with type 2 diabetes mellitus, obesity and cardiovasculare dieseas. IR can be quantified using detailed protocols, such as the euglycemic-hyperinsulinemic clamp (EC) technique and the intravenous glucose tolerance test, or based on indices derived from the oral glucose tolerance test. Although these indices showed greater association with the i...

Introduction: Fine-needle aspiration (FNA) is indicated in suspicious thyroid nodules or big ones. Bethesda system classifies them according to the cytological malignancy risk. Bethesda category 4 (B4) comprises follicular neoplasms and suspicious follicular neoplasms. Aim: Determine final diagnosis of B4 nodules and study associations between malignancy and other variables.Methods: Retrospective study of patients with nodules classified as B4 a...

BackgroundThe prevalence of malignancy among Bethesda category III (atypia of undetermined significance) cytologies is variable in different studies.ObjectiveThe aim of this paper is to evaluate the risk of malignancy of thyroid nodules classified as Bethesda III in our hospital.MethodsWe have reviewed the medical records of 146 patients who underwent FNA with Bet...

Objective: This study aims to assess the utility of salivary cortisol (SC) in diagnosing adrenal insufficiency (AI) and to analyze the integrity of the hypothalamic-pituitary-adrenal axis. This involves evaluating cortisol rhythm, its correlation with plasma levels, and the impact of exogenous hydrocortisone (HC) substitution on SC determination.Methods: A prospective study was conducted on all patients with suspected AI undergoing adrenocorticotropic ho...

Backround and objectives: Heart failure (HF) has a rising incidence and is one of the most prevalent diseases worldwide. The number of patients with type 2 diabetes (T2DM) with heart failure is very high. Serum NT-proBNP and systolic ejection fraction correlate with the severity and prognosis of this condition. The nutritional evaluation of patients with HF, who usually have normal weight, overweight or obesity, has acquired a novel approach due to the incorporation of novel t...